简介：

仇波，男，主任医师，教授，毕业于中国医科大学，医学博士，硕士生导师，擅长各种脑肿瘤与脊髓肿瘤，脑积水，以及小儿神经外科疾病，功能性疾病（继发性癫痫，三叉神经痛，面肌痉挛等），颅脑损伤和颅脑畸形的诊断与治疗。目前任辽宁省抗癫痫协会理事，主持省自然科学基金一项，承担及参与多项国家级及省部级课题研究，国内外发表文章100余篇，获得辽宁省科技进步二等奖一项。参与及已完成课题1.白介素-6对胶质瘤干细胞免疫调控及侵袭性影响的机制研究，辽宁省自然科学基金，2013-2016.2.色觉视蛋白基因在视网膜锥体细胞内排他性表达机制的分子遗传学研究(国家自然科学基金青年科学基金项目，项目批准号：81000402， 2011.01-2013.123.氧自由基在脑缺血后迟发性神经细胞死中作用的活体荧光成像研究（国家自然科学基金青年科学基金项目，项目批准号：81000565，2011.1-2013.12）4. FoxM1B调控PDGF信号通路参与促进胶质瘤干细胞自我更新及诱导血管新生的机制研究（2012.1-2014.12，国家自然科学基金青年科学基金项目，项目批准号：81101917）5. 脑胶质瘤干细胞增殖分化机制的研究（辽宁省科学技术厅攻关项目，编号2007408001-5，2007-2010）6. 脑卒中的规范化治疗（ 国家十一五科技支撑计划课题子课题,2008-2010）7. peg-PLGA-长春新碱高靶向纳米颗粒与胶质瘤的作用（国家863项目，北京天坛神经外科研究所合作课题，2009.11-2010.11）8. SAH与脑动脉瘤诊断与治疗的规范化研究（国家十一五科技支撑计划课题子课题, 2007-2009）9. 术中实时荧光血管造影在脑显微外科中的应用研究（辽宁省高等学校科技计划项目, 2007-2009）文章列表[1] Qiu B, Zhang D, Wang C, Tao J, Tie X, Qiao Y, Xu K, Wang Y, Wu A. IL-10 and TGF-β2 are overexpressed in tumor spheres cultured from human gliomas. Mol Biol Rep. 2011 Jun;38(5):3585-91.[2] Qiu B, Zhang D, Tao J, Tie X, Wu A, Wang Y. Human brain glioma stem cells are more invasive than their differentiated progeny cells in vitro. J Clin Neurosci. 2012 Jan;19(1):130-4.[3] Qiu B, Zhang D, Tao J, Wu A, Wang Y. A simplified and modified procedure to culture brain glioma stem cells from clinical specimens. Oncol Lett. 2012 Jan;3(1):50-54.[4] Wang Y, Qiu B, Li P, Cheng P, Li G, Li X, Xu H, Wang Y. Multifocal intraparenchymal Langerhans' cell histiocytosis concomitant with an arachnoid cyst in a child: case report and review of the literature. J Child Neurol. 2012 Jun;27(6):767-78. (并列第一作者)[5] Qiu B, Wang Y, Tao J, Wang Y. Expression and correlation of Bcl-2 with pathological grades in human glioma stem cells. Oncol Rep. 2012 Jul; 28(1):155-160. 2.297[6] Qiu B, Sun X, Zhang D, Wang Y, Tao J, Ou S. TRAIL and Paclitaxel Synergize to Kill U87 Cells and U87-Derived Stem-Like Cells in Vitro. Int J Mol Sci. 2012; 13(7):9142-9156. 2.464[7] Qiu B, Zhang D, Wang Y, Ou S, Wang J, Tao J, Wang Y. Interleukin-6 is overexpressed and augments invasiveness of human glioma stem cells in vitro. Clin Exp Metastasis. 2013 Dec;30(8):1009-1018. DOI: 10.1007/s10585-013-9599-0. PubMed PMID: 23832741. 3.725[8] Qiu B, Li X, Sun X, Wang Y, Jing Z, Zhang X, Wang Y. Overexpression of aquaporin-1 aggravates hippocampal damage in mouse traumatic brain injury models. Mol Med Rep. 2014 Mar; 9(3):916-22. doi: 10.3892/mmr.2014.1899. PubMed PMID: 24430824. 1.554[9] Qiu B, Ou S, Song T, Hu J, You L, Wang Y, Wang Y. Intraoperative electrocorticography-guided microsurgical management for patients with onset of supratentorial neoplasms manifesting as epilepsy: a review of 65 cases. Epileptic Disord. 2014 Jun 1; 16(2):175-84. doi: 10.1684/epd.2014.0662. PubMed PMID:24866815. 0.954[10] Qiu B, Wang Y, Ou S, Guo Z, Wang Y. The unilateral occipital transtentorial approach for pineal region meningiomas: A report of 15 cases. Int J Neurosci. 2014 Oct; 124(10):741-7. doi: 10.3109/00207454.2013.878341. PubMed PMID: 24397496. Epub 2014 Feb 7. 1.521[11] Qiu, B., Wang, Y., Wang, W., Wang, C., Wu, P., Bao, Y., Ou, S., Guo, Z., Wang, Y. Microsurgical management of pediatric ependymomas of the fourth ventricle via the trans-cerebellomedullary fissure approach: A review of 26 cases. Oncology Letters. 2016; 11 (6): 4099-4106. http://dx.doi.org/10.3892/ol.2016.4507 1.3899[12] Du Jiang, Qiu Bo, Wang Yong, Tao, Jun Ou Shaowu, Wang Yunjie. Sellar Reconstruction Using Biomaterials After Transsphenoidal Surgery in 449 Cases of Pituitary Adenomas. Neurosurgery Quarterly. 2014 Feb; 24(1):22-26. doi: 10.1097/WNQ.0b013e31828c75d0(并列第一作者)[13] Jun Tao, Yunjie Wang, Bo Qiu, Shaowu Ou, Yong Wang, Pengfei Wu. Selection of surgical approaches based on semi-quantifying the skull-base invasion by petroclival meningiomas: a review of 66 cases. Acta Neurochirurgica. June 2014; 156(6):1085-1097. DOI: 10.1007/s00701-014-2084-y (通讯作者) 1.788[14] Qu, M., Qiu, B., Xiong, W., Chen, D., Wu, A. Expression of a-disintegrin and metalloproteinase 10 correlates with grade of malignancy in human glioma. Oncology Letters. 2015; 9(5): 2157-2162. http://dx.doi.org/10.3892/ol.2015.2993(并列第一作者)[15] Wu P, Liang C, Wang Y, Guo Z, Li B, Qiu B, Li X, Wen Z, Pan Q. Microneurosurgery in combination with endovascular embolisation in the treatment of solid haemangioblastoma in the dorsal medulla oblongata. Clin Neurol Neurosurg. 2013 Jun; 115(6):651-657. doi: 10.1016/j.clineuro.2012.07.026. PubMed PMID: 22906819.[16] Zhang H, Wang Y, Lu T, Qiu B, Tang Y, Ou S, Tie X, Sun C, Xu K, Wang Y. Differences between generalized q-sampling imaging and diffusion tensor imaging in the preoperative visualization of the nerve fiber tracts within peritumoral edema in brain. Neurosurgery. 2013 Dec; 73(6):1044-1053. doi:10.1227/NEU.0000000000000146. PubMed PMID: 24056318.[17] Lu WC, Li GY, Xie H, Qiu B, Yang RM, Guo ZZ. Erythromycin pretreatment induces tolerance against focal cerebral ischemia through up-regulation of nNOS but not down-regulation of HIF-1α in rats. Neurol Sci. 2014 May; 35(5):687-93. Doi: 10.1007/s10072-013-1584-5. PubMed PMID: 24277204.[18] Wang J, Guo ZZ, Wang YJ, Qiu B, Xing DG. Microsurgical management of bronchogenic cysts in the thalamus: an illustrative case and literature review. Br J Neurosurg. 2014 Aug; 28(4):516-9. Doi: 10.3109/02688697.2013.854315. PubMed PMID: 24168658. [19] Daling Ding, Ailing Zhao, Bo Qiu, Deguang Xing, Gefei Guan, Zongze Guo. Ependymoblastoma with cystic change in a child: Case report. Journal of Neurosurgery: Pediatrics 13(6): 658-665. DOI: 10.3171/2014.3.PEDS13405.[20] Xing D, Wang J, Ou S, Wang Y, Qiu B, Ding D, Guo F, Gao Q. Expression of neonatal Nav1.5 in human brain astrocytoma and its effect on proliferation, invasion and apoptosis of astrocytoma cells. Oncol Rep. 2014 Jun; 31(6): 2692-2700. doi: 10.3892/or.2014.3143. PubMed PMID: 24756536.[21] Wang J, Guo Z, Ma E, Xing D, Qiu B, Wang Y. Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review. Oncology Letters, 2015 April; 9(4): 1795-1801. DOI: 10.3892/ol.2015.2903[22] Wang J, Ma EM, Wu PF, And BQ, Wang YJ. Multiple intracranial and spinal metastases from a nonfunctioning pituitary adenoma following multiple surgeries: an illustrative case with 16 years of follow-up. World J Surg Oncol. 2014 Dec 12; 12:380(1-7). doi: 10.1186/1477-7819-12-380. PubMed PMID: 25494704; PMCID: PMC4295575.[23] Tian A, Qin XF, Wu A, Zhang H, Xu Q, Xing D, Yang H, Qiu B, Xue X, Zhang D, Dong C. Nanoscale TiO2 nanotubes govern the biological behavior of human glioma and osteosarcoma cells. International Journal of Nanomedicine. 2015, 10:2423-2439. doi: dx.doi.org/10.2147/IJN.S71622[24] Han S, Li X, Qiu B, Jiang T, Wu A. Can lateral ventricle contact predict the ontogeny and prognosis of glioblastoma? J Neurooncol. 2015 Aug; 124(1): 45-55. doi: 10.1007/s11060-015-1818-x. PubMed PMID: 26007164. [25] Guan Y, Chen L, Bao Y, Qiu B, Pang C, Cui R, Wang Y. High miR-196a and low miR-367 cooperatively correlate with unfavorable prognosis of high-grade glioma. Int J Clin Exp Pathol. 2015 Jun 1;8(6):6576-88. eCollection 2015. PubMed PMID: 26261539; PubMed Central PMCID: PMC4525873.[26] Wang J, Xing DG, Ma EM, Qiu B, Ou SW, Wang YJ. Microsurgical Outcomes of Secondary Epilepsy from Hippocampal Lesions: A Report of 56 Cases and Literature Review. Turk Neurosurg. 2016; 26(1): 29-38. doi: 10.5137/1019-5149.JTN.11314-14.2. PubMed PMID: 26768866.[27] Cui R, Guan Y, Sun C, Chen L, Bao Y, Li G, Qiu B, Meng X, Pang C, Wang Y. A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma. Cancer Lett. 2016 Feb 10. pii: S0304-3835(16)30041-6. doi: 10.1016/j.canlet.2016.01.051. [Epub ahead of print] PubMed PMID: 26854715.[28] Zhang D, Qiu B, Wang Y, Guan Y, Zhang L, Wu A. Temozolomide increases MHC-I expression via NF-κB signaling in glioma stem cells. Cell Biol Int. 2017 Jun;41(6):680-690. doi: 10.1002/cbin.10773. Epub 2017 May 2. PubMed PMID: 28403532.[29] Wang J, Ou SW, Zhang ZY, Qiu B, Wang YJ. Molecular expression of multiple Nav1.5 splice variants in the frontal lobe of the human brain. Int J Mol Med. 2018 Feb;41(2):915-923. doi: 10.3892/ijmm.2017.3286. Epub 2017 Nov 24. PubMed PMID: 29207052; PubMed Central PMCID: PMC5752160.[30] Yiwei Wang, Jin Zang, Dongyong Zhang, Zhenxiang Sun,Bo Qiu, Xiaojie Wang. KDM2B overexpression correlates with poor prognosis and regulates glioma cell growth. January 2018, OncoTargets and Therapy Volume 11:201-209. Doi: 10.2147/OTT.S149833[31] Tao J, Qiu B, Zhang D, Wang Y. Expression levels of Fas/Fas-L mRNA in human brain glioma stem cells. Mol Med Report. 2012 May;5(5):1202-6.[32] Sun X, Pang Z, Ye H, Qiu B, Guo L, Li J, Ren J, Qian Y, Zhang Q, Chen J, Jiang X. Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome. Biomaterials. 2012 Jan;33(3):916-24.[33] Zhang D, Tian A, Xue X, Wang M, Qiu B, Wu A. The Effect of Temozolomide/Poly (lactide-co-glycolide) (PLGA)/Nano-Hydroxyapatite Microspheres on Glioma U87 Cells Behavior. Int J Mol Sci. 2012;13(1):1109-25. [34] Zhang D, Jing Z, Qiu B, Wu A, Wang Y. Temozolomide decreases invasion of glioma stem cells by down-regulating TGF-β2. Oncol Rep. 2011 Oct;26(4):901-8.[35] Wang W, Chen H, Li Q, Qiu B, Wang J, Sun X, Xiang Y, Zhang J. Fasting plasma glucose is an independent predictor for severity of H1N1 pneumonia. BMC Infect Dis. 2011 Apr 21;11:104.[36] Wang C, Cao S, Tie X, Qiu B, Wu A, Zheng Z. Induction of cytotoxicity by photoexcitation of TiO2 can prolong survival in glioma-bearing mice. Mol Biol Rep. 2011 Jan; 38(1):523-30.[37] Wang W, Qiu B, Li Q, Chen H, Xu W. CT onset of influenza A (H1N1) complicated with severe pneumonia in two typical cases. Panminerva Med. 2010 Dec;52(4):355-9. [38] Tian A., Wang C., Xue X., Wu A., Guan G., Wang L., Qiu B. Inhibitory effect of nano-ha particles on human u87 glioblastoma cells viability. J. Inorg. Mater. 2010; 25:101–106[39] 仇波,郭宗泽,董克辛,曲波,姜大宇,刘志超,刘业俭. OLIG1对人少突胶质细胞瘤鉴别诊断意义的研究[J]. 中华神经外科杂志,2005,03:46.[40] 仇波,张东勇,陶钧,吴安华,王运杰. 一种简化改良的脑胶质瘤干细胞培养方法[J]. 中国神经肿瘤杂志,2011,01:7-11.[41] 仇波,王勇,陶钧,铁欣昕,夏俊哲,刘源,王运杰. 21例大型及巨大型颅咽管瘤患者术后水钠失衡的处理[J]. 中国现代医学杂志,2011,21（29）:3672-3675.[42] 仇波,张东勇,陶钧等.人脑胶质瘤干细胞中IL-10的mRNA表达[J].中华神经外科疾病研究杂志,2011,10(6):485-488.[43] 仇波,张东勇,陶钧等.人脑胶质瘤干细胞TGF-β2 mRNA的表达及意义[J].中华神经医学杂志,2012,11(1):11-15.[44] 仇波,秦晓飞,王勇,王运杰. 脑外伤小鼠海马血管内皮生长因子表达的变化[J]. 解剖科学进展,2012,18（2）:119-121+125.[45] 仇波,杜江,张东勇,陶钧,王勇,王运杰. 人脑胶质瘤组织培养的干细胞样细胞具有体外高侵袭能力[J]. 中国肿瘤生物治疗杂志,2012,19(2):128-132.[46] 仇波,王勇,秦晓飞等.脑外伤小鼠海马水通道蛋白-9表达的变化[J].解剖学研究,2012,34(2):100-103.[47] 仇波,王勇,刘源等.449例经鼻蝶入路垂体瘤切除术后鞍底重建[J].中国肿瘤临床,2012,39(9):611-614.[48] 仇波,刘源,王勇. 脑外伤小鼠海马TNF-α表达的变化[J]. 中国医科大学学报,2012,41(6):504-506.[49] 仇波,王勇,吴鹏飞,秦晓飞,王运杰. 神经干细胞移植显著改善脑外伤小鼠的神经功能[J]. 解剖科学进展,2012,18(3):201-204.[50] 仇波,王勇,陶钧等.人工硬脑膜扩大修补术治疗Arnold-Chiari畸形合并脊髓空洞17例分析[J].中国医师进修杂志,2012,35(17):57-59.[51] 郭宗泽,仇波,陈东等.铊-201单光子计算机断层扫描在探测胶质瘤复发的价值[J].中华神经外科杂志,2005,21(9):559-561.[52] 陶钧,仇波.人脑胶质瘤干细胞Fas/Fas-L mRNA表达的研究[J].中华肿瘤防治杂志,2011,18(18):1450-1454.[53] 王勇,仇波,杜江,王运杰. 慢性硬膜下血肿钻孔冲洗引流术中两种冲洗液疗效对比[J]. 山西医药杂志,2012,01:6-7.[54] 李光宇,郭宗泽,陈东,仇波,夏名飞. ~(201)Tl吸收指数与复发胶质母细胞瘤患者生存相关性的研究[J]. 中华肿瘤防治杂志,2006,12:917-919.[55] 田昂,王超,薛向欣,吴安华,管格非,王丽,仇波. 纳米羟基磷灰石对人脑胶质母细胞瘤U87细胞活性抑制效应的研究(英文)[J]. 无机材料学报,2010,01:101-106.[56] 李连祥,仇波,张东勇,王运杰. 原发脑干损伤并发神经源性肺水肿19例诊疗体会[J]. 山东医药,2011,08:87-88.[57] 董克辛，仇波，曲波，姜大宇. 经皮微球囊压迫半月节治疗三叉神经痛[J].立体定向和功能性神经外科杂志，2004，17(6)：369-370.[58] 仇波,王勇,程鹏,李光宇,李心国,王运杰. 儿童脑内多灶性朗格汉斯组织细胞增生症一例并文献复习[J].中华神经外科杂志，2012；28（10）：1015-1018.[59] 仇波,吴鹏飞,王勇,陶钧,欧绍武,王运杰. TRAIL联合紫杉醇对人脑胶质瘤U87细胞的抑制效应及其可能的机制[J]. 中国肿瘤生物治疗杂志，2013；20（1）：591-595.[60] 仇波,林毅,王勇,陶钧,欧绍武,王运杰. 紫杉醇在TRAIL诱导脑胶质瘤干细胞凋亡中的增敏作用研究[J]. 现代肿瘤医学, 2013; 21(3): 463-467.[61] 张东勇,仇波,王运杰.胶质瘤治疗的新靶点：TGF-β2[J].分子诊断与治疗杂志,2013,5(2):123-127.[62] 王军,郭宗泽,王运杰,欧绍武,王义宝,邢德广,仇波,李婷. 颅内恶性黑色素瘤的显微外科治疗:二例报告及文献复习[J]. 中国现代神经疾病杂志,2013,13(05):447-452.[63] 王明昊，仇波*，王勇，王军，班允超，崔晓，景治涛，王运杰.δ-catenin在星形细胞瘤中过表达并促进其增殖与侵袭能力[J].中国神经肿瘤杂志，2013，11(2)：79-85.[64] 张东勇，吴安华，王运杰，仇波*.替莫唑胺抑制胶质瘤细胞系U251体外侵袭能力的研究[J].中国神经肿瘤杂志，2013，11（2）：108-112.[65] 仇波，林毅，王勇，陶钧，王运杰. Bcl-2在人脑胶质瘤干细胞样细胞中的表达及病理相关性[J]. 中华神经外科疾病研究杂志,2013,12(4): 305-309.[66] 仇 波,张东勇,林 毅,张世刚,王运杰. 经小脑延髓裂显微外科切除第四脑室肿瘤（附22例报告）[J].现代肿瘤医学,2013,21(10) : 2211-2214.[67] 仇波,张恒,王勇,王军,欧绍武,王运杰. 颅内海绵状血管瘤的诊断与显微外科治疗[J].中国微侵袭神经外科杂志,2013,18(09):389-391.[68] 韩鹏,仇波,张世刚等.幕上原始神经外胚层肿瘤1例报告并文献复习[J].山东医药,2013,53(18):90-92.DOI:10.3969/j.issn.1002-266X.2013.18.035.[69] 赵丹，包义君，仇波，王勇，王运杰. 颅脑开颅术后无菌性脑膜炎的预后[J].中国医科大学学报,2013,42(7):623-625.[70] 邢德广,王军,王运杰,欧绍武,丁大岭,管格非,仇波.电压-门控钠离子通道Nav1.5与肿瘤关系进展[J].现代肿瘤医学,2013,21(11):2596-2601.[71] 包义君,王维,王鹏飞,仇波,吴安华,王运杰. YAP对胶质瘤细胞系U87MG细胞迁移的促进作用[J].神经疾病与精神卫生, 2013, 13(5): 453-456. [72] 王键,尹秀茹,仇波,王运杰,裴凌. 氯胺酮对脑电双频指数和熵指数的影响[J]. 神经疾病与精神卫生, 2013, 13(6): 599-602.[73] 王军,仇波,王运杰,郭宗泽,邢德广,王义宝,吴鹏飞,张东勇,杜江. 原发性中枢神经系统淋巴瘤的诊断和治疗[J]. 神经疾病与精神卫生, 2013, 13(6): 588-594.[74] 仇波, 李心国, 王勇, 王军, 王运杰. 颅脑创伤模型小鼠海马水通道蛋白1表达及作用[J]. 中国现代神经疾病杂志，2014, 14 (3): 245-251.[75] 王军,吴鹏飞,仇波,郭宗泽,张世刚,邢德广,王运杰.合并Ota痣的脑膜恶性黑色素瘤的显微外科治疗[J]. 神经疾病与精神卫生, 2014, 14(1):98-104. 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擅长手术治疗脑膜瘤、胶质瘤、听神经瘤、颅咽管瘤等各种复杂颅脑肿瘤，椎管内肿瘤，脑积水，以及小儿神经外科疾病、和功能性神经外科疾病（三叉神经痛，面肌痉挛，癫痫）等。

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